Smile! Protein and peptide sample preparation automated

Dedicated instrumentation to improve sample throughput for LC-MS analysis - compatible with all the iST workflows

The challenge:

How do you bring further standardization, reproducibility and hands on time savings to proteomics sample preparation for LC-MS analysis when you have already successfully addressed the many challenges of time, sample contamination, sample loss and reproducibility?

The solution:

Automate! Introducing the PreON® platform; built to address the demands of reproducible, robust and sensitive proteomics sample preparation for LC-MS analysis. It allows research labs to automate proteomics processing at the push of a button decreasing the hands-on time from 1 hour (iST, iST-NHS and iST-BCT sample preparation) to about 5 minutes!

Apply! Simple, streamlined workflows

1. Samples

Samples should be liquid, homogenates or a soft pellet.

2. Lyse, reduce, alkylate

Add LYSE reagent, incubate for 10 mins at high temperature.

3. Digest and label

Cool, add DIGEST reagent, incubate for 60 mins at 37°C. Label according to vendor instructions.

4. Purify

Load onto cartridge, WASH and ELUTE. Dry and resuspend in LOAD.

5. LC-MS analysis

Inject and analyze to see improved peptide identities.

Results

The PreON® eliminates manual processing errors and pipetting variability, improving quality and reproducibility. Spend less time preparing your samples, increase throughput and achieve better results.

The PreON® significantly reduces variability in chemically-labeled proteomics sample preparation by reducing manual steps and eliminating processing errors. Spend less time preparing your samples while achieving better results.

PreOmics^®'

PreON®

values

Smile

Improved sample quality

High reproducibility: R²>0.9
Working range: 1-100 µg
Increased peptide and protein identifications
Benchtop footprint (0.81 x 0.65 x 0.62 m HxWxD, weight 71.5kg)
Installation and training included

Relax

Sample preparation fully automated

Can prepare up to 12 unlabeled and 16 labeled samples (standard configuration)
18 labeled samples can now be processed with the new TMTpro^TM 18-plex upgrade set*
True walk-away automation for label-free and chemical labeling workflows
Eliminates manual processing steps (only 5 mins hands on time)
Works seamlessly with pre-loaded PreOmics® protocols
PreON® is installed and running samples in less than a day
Intuitive touch screen menus
Overnight evaporation option
Range of service plans available

*PreON® upgrade set including a purpose-built hardware set and software package. For more information, reach out to your regional sales representative or info@preomics.com.