Smile! Redefining proteomics depth for plasma samples

Deep, reproducible, and scalable human plasma sample enrichment for unparalleled protein identifications

The challenge:

Plasma proteomics often struggles with insufficient depth and dynamic range issues. High-abundance proteins overshadow low-abundance targets, leading to incomplete datasets. Especially in the field of biomarker analysis and drug discovery, deep access to the human plasma proteome is crucial. Conventional workflows also introduce variability, lack reproducibility, and are poorly suited for high-throughput studies, making true proteome exploration impractical.

The solution:

ENRICHplus offers deeper proteome access for human EDTA plasma samples, boosting protein identifications up to 7x. With CVs of ~11% and exceptional reproducibility, this easy-to-use kit supports both manual and automated workflows, making it ideal for large-scale studies. The all-in-one kit takes you from neat human plasma to peptides in less than 5 hours, combining precision with speed. Designed for plasma-specific use, ENRICHplus provides a streamlined plasma preparation platform for when full access to the proteome at an affordable price really counts.

Apply! Simple, streamlined workflows

1. Sample

Samples should be human EDTA plasma.

2. ENRICH

Add sample to prepared ENplus-BEADS and incubate for 30 min at 30°C.

3. Lyse, reduce, alkylate

Add LYSE reagent and incubate for 10 min at 60°C.

4. Digest

Cool, add DIGEST reagent, and incubate for 1 h at 37°C.

5. Purify

Load onto the cartridge, WASH, and ELUTE. Dry and resuspend in LC-LOAD.

6. MS analysis

Inject and analyze to see improved peptide identities.

Results

Time flies with PreOmics® ENRICHplus sample preparation

While standard proteomics sample preparation takes up to 44 hours – the same time as flying around the world non-stop, PreOmics® kits take the same time as flying from our Munich HQ to London or from Boston to Chicago. Increase your sample throughput, improve quality and produce reliable data. It’s as easy as i-S-T!